This study investigated the effect of an innovative chilling device that intends to make subjects more alert and less sleepy. Tests were conducted using a variety of methods including electric-encephalography (EEG) brain tomography. A series of behavioral tests showed an increase in alertness, changes of body temperatures, and performance indicators after usage of this device. The device chills specific areas of the body and disrupts the body’s ability to self-regulate core body temperature. The induced temperature shifts may reduce the body’s capability to go to sleep. Physiological changes and brain wave indicators of alertness were also reviewed in this paper. A full study of alertness indicators in expanded driver simulations is recommended. As for future application of this device to Human Factors aspects, this device may have the potential to enhance alertness in the human dimension of machine operation of manned and unmanned assets with further improvement.