Today’s weapon systems are becoming increasingly complex and usually involve other assets to accomplish their missions. Interdependencies among the weapon system components such as its sensor, sensor subsystems, communications, navigation, etc., are crucial to the System Engineering (SE) design and test process. Inserting the individual weapon system into a larger context of a System-of-Systems (SoS) and Family of Systems (FoS) increases the Test and Evaluation (T&E) complexity exponentially. The ability to readily orchestrate myriad of test conditions and scenario alterations in a SoS/FoS context must be devised to enable the evaluation of alternative designs in order to adapt to future missions, threats, and technologies. This paper will address the coupling of Modeling and Simulation (M&S) and systems engineering to support cost-effective decisions on concept development, technology evaluation, material, doctrine, tactics, combat techniques and force structure. Current information technology (IT) trends, e.g., virtualization, cloud computing, micro-services, containerization, etc., helps manage the orchestration of tests on the M&S testbed.