This work presents the development and application of an optimization algorithm for simultaneously improving the fatigue life and minimizing a representative manufacturing cost when assembling a ground combat vehicle. High stress in the occupied space of the weld decreases of a welded structure while reducing a manufacturing cost is demonstrated by considering the the fatigue life of the structure; therefore, by minimizing the weld’s exposure to high stresses, the structure’s life can be improved. The new capability for simultaneously improving the fatigue life welding of a representative panel of a v-hull. Selections are made for the weld placement, the weld type, and the type of filler material, in order to minimize exposure to high stresses and therefore maximize fatigue life. In addition to the stress evaluation, the optimization considers manufacturing cost as another objective in parallel. The final evaluation provides an assembly design to increase the fatigue life and minimize cost.